Suzuki Hideaki
   Department   School of Medicine  Otorhinolaryngology-Head and Neck Surgery, Clinical Medical Sciences
Article types journal article
Language English
Peer review Peer reviewed
Title Synchronized roles of pannexin and connexin in nasal mucosal epithelia.
Journal Formal name:European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Abbreviation:Eur Arch Otorhinolaryngol
ISSN code:14344726/09374477
Domestic / ForeginForegin
Volume, Issue, Page 275(6),1657-1661頁
Author and coauthor Ohbuchi Toyoaki, Suzuki Hideaki
Publication date 2018/06
Summary BACKGROUND:Nasal mucosal epithelial cells express connexins, the prototypical gap junction proteins, and pannexins, a new family of channel proteins homologous to the invertebrate gap junction proteins. The physiological and pathophysiological roles of these transmembrane proteins in nasal mucosa are largely still unknown.PURPOSE:Pannexins participate in ATP release into the extracellular space in various tissues, and ATP plays important roles in mucociliary clearance, especially by regulating ciliary beat activity. Therefore, we focused on the functional relationship between connexins, pannexin-1, ATP release, and mucociliary clearance in nasal epithelia.RESULTS AND CONCLUSIONS:Connexins participate in the generation of intercellular calcium waves, in which calcium-mediated signaling responses spread to contiguous cells through the gap junction formed by connexins to transmit calcium signaling throughout the airway epithelium. Pannexins in the nasal mucosa may contribute to not only ciliary beat modulation via ATP release, but also regulation of mucus blanket components via H2O efflux. The synchronized roles of pannexin and connexin may provide a new insight into effective mucociliary clearance systems in nasal mucosa.
DOI 10.1007/s00405-018-4947-y
PMID 29574598