Fujimoto Naohiro
   Department   School of Medicine  Urology, Clinical Medical Sciences
   Position  
Article types 不明
Language English
Peer review Non peer reviewed
Title Effects of nitric oxide synthase isoform deletion on oxytocin and vasopressin messenger RNA in mouse hypothalamus.
Journal Formal name:Neuroreport
Abbreviation:Neuroreport
ISSN code:09594965/09594965
Domestic / ForeginForegin
Volume, Issue, Page 16(4),413-7頁
Author and coauthor Nomura Masayoshi, Tsutsui Masato, Shimokawa Hiroaki, Fujimoto Naohiro, Ueta Yoichi, Morishita Tsuyoshi, Yanagihara Nobuyuki, Matsumoto Tetsuro
Publication date 2005/03
Summary The effects of neuronal, endothelial, or inducible nitric oxide synthase gene disruption on the expression of oxytocin and vasopressin gene were examined in the hypothalamus (paraventricular, supraoptic, suprachiasmatic, and anterior commissural nuclei) and extrahypothalamus (bed nucleus of the stria terminalis). The oxytocin messenger RNA levels in the anterior commissural nucleus of neuronal nitric oxide synthase knockout mice were significantly higher than in control mice, but not in endothelial or inducible nitric oxide synthase knockout mice. In contrast, no significant effects of neuronal, endothelial, or inducible nitric oxide synthase gene disruption on oxytocin and vasopressin messenger RNA levels in the other hypothalamic and extrahypothalamic nuclei were observed. These results suggest that neuronal nitric-oxide-synthase-derived nitric oxide may be involved in the regulation of oxytocin gene expression in the anterior commissural nucleus.
PMID 15729148