Fujimoto Naohiro
   Department   School of Medicine  Urology, Clinical Medical Sciences
Article types 不明
Language English
Peer review Non peer reviewed
Title Multiple biopsies of normal-looking urothelium in patients with superficial bladder cancer: Are they necessary?
Journal Formal name:International journal of urology : official journal of the Japanese Urological Association
Abbreviation:Int J Urol
ISSN code:09198172/09198172
Domestic / ForeginForegin
Volume, Issue, Page 10(12),631-5頁
Author and coauthor Fujimoto Naohiro, Harada Shuji, Terado Michikazu, Sato Hideki, Matsumoto Tetsuro
Publication date 2003/12
Summary BACKGROUND:The objective of the study presented here was to assess the usefulness and indications of multiple biopsies of normal-appearing urothelium in patients with superficial bladder cancer.METHODS:Between December 1996 and December 2002, multiple biopsies of normal-appearing bladder mucosa were performed in 100 patients with superficial bladder transitional cell carcinoma. Biopsy specimens were taken from seven different sites in females and nine different sites in males.RESULTS:In eight of 100 patients, bladder cancers were detected in the biopsy specimens. Three cases were Ta and five were Tis. All of the five patients with carcinoma in situ (CIS) in their biopsy specimens had multiple papillary broad-base tumors and positive urinary cytology. The detection ratio of CIS in patients with these findings was 17.9% (5/28). No concomitant CIS was detected in the 72 patients who had a solitary tumor, pedunculated tumor(s), or negative urinary cytology.CONCLUSION:Multiple mucosal biopsies of normal-appearing urothelium are not necessary for all patients with superficial bladder cancer. They are, however, necessary for patients with multiple papillary broad-base tumors and positive urinary cytology.
PMID 14633065