Fujimoto Naohiro
   Department   School of Medicine  Urology, Clinical Medical Sciences
Article types journal article
Language English
Peer review Peer reviewed
Title The detection of microorganisms related to urethritis from the oral cavity of male patients with urethritis.
Journal Formal name:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Abbreviation:J Infect Chemother
ISSN code:14377780/1341321X
Domestic / ForeginForegin
Volume, Issue, Page 23(10),668-673頁
Author and coauthor Le Phuong Thi, Hamasuna Ryoichi, Matsumoto Masahiro, Furubayashi Keiichi, Hatanaka Masayuki, Kawai Shuichi, Yamaguchi Takamasa, Uehara Kazutaka, Murakami Norihiko, Yoshioka Masaru, Nakayama Ken, Shiono Yutaka, Muraoka Keisuke, Suzuki Masahiko, Fujimoto Naohiro, Matsumoto Tetsuro
Publication date 2017/10
Summary OBJECTIVES:To investigate the presence of microorganisms related to urethritis in the oral cavity of male patients with urethritis and the efficacies of antimicrobials for urethritis on microorganisms in the oral cavity.METHODS:Ninety-two male patients with urethritis and 17 male controls participated to this study at 12 urology clinics in Japan between March 2014 and March 2015. The first voided urine (FVU) and oral wash fluid (OWF) specimens were collected from the participants. The microorganisms in both FVU and OWF specimens were detected by nucleic acid amplification tests at the first and follow-up visit. The efficacies of antimicrobials were evaluated after 1-4 weeks treatment completion.RESULTS:In a total of 92 male patients with urethritis, Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum, Ureaplasma parvum, Trichomonas vaginalis and Gardnerella vaginalis were detected from OWF specimens of 12%, 3%, 9%, 0%, 12%, 3%, 3% and 15% patients, respectively. From control males, no microorganism was detected from OWF specimens. Among 46 patients who could be evaluated for antimicrobial efficacies at the follow-up visit, 5 in FVU specimens failed by azithromycin (AZM), and 10 failed in OWF specimens (7 by AZM, 2 by tetracycline, 1 by spectinomycin; p = 0.002). Especially, a high prevalence of G. vaginalis remained positive after treatment for urethritis in the oral cavity.CONCLUSION:Microorganisms related to urethritis were detected in the oral cavity of male patients with urethritis. Antimicrobials that focused on urethritis, especially AZM regimen seem to be less effective for microorganisms in the oral cavity.
DOI 10.1016/j.jiac.2017.06.011
PMID 28803864