Fujimoto Naohiro
   Department   School of Medicine  Urology, Clinical Medical Sciences
Article types journal article
Language English
Peer review Peer reviewed
Title Human mitochondrial transcription factor A functions in both nuclei and mitochondria and regulates cancer cell growth.
Journal Formal name:Biochemical and biophysical research communications
Abbreviation:Biochem Biophys Res Commun
ISSN code:10902104/0006291X
Domestic / ForeginForegin
Volume, Issue, Page 408(1),45-51頁
Author and coauthor Han Bin, Izumi Hiroto, Yasuniwa Yoshihiro, Akiyama Masaki, Yamaguchi Takahiro, Fujimoto Naohiro, Matsumoto Tetsuro, Wu Bin, Tanimoto Akihide, Sasaguri Yasuyuki, Kohno Kimitoshi
Publication date 2011/04
Summary Mitochondrial transcription factor A (mtTFA) is one of the high mobility group protein family and is required for both transcription from and maintenance of mitochondrial genomes. However, the roles of mtTFA have not been extensively studied in cancer cells. Here, we firstly reported the nuclear localization of mtTFA. The proportion of nuclear-localized mtTFA varied among different cancer cells. Some mtTFA binds tightly to the nuclear chromatin. DNA microarray and chromatin immunoprecipitation assays showed that mtTFA can regulate the expression of nuclear genes. Overexpression of mtTFA enhanced the growth of cancer cell lines, whereas downregulation of mtTFA inhibited their growth by regulating mtTFA target genes, such as baculoviral IAP repeat-containing 5 (BIRC5; also known as survivin). Knockdown of mtTFA expression induced p21-dependent G1 cell cycle arrest. These results imply that mtTFA functions in both nuclei and mitochondria to promote cell growth.
DOI 10.1016/j.bbrc.2011.03.114
PMID 21453679