オカダ ヨウスケ   Okada Yosuke
  岡田 洋右
   所属   医学部医学科  臨床医学系 第1内科学
   職種   准教授
論文種別 症例報告
言語種別 英語
査読の有無 査読あり
表題 The Effects of Mitiglinide and Repaglinide on Postprandial Hyperglycemia in Patients Undergoing Methylprednisolone Pulse Therapy.
掲載誌名 正式名:Internal medicine (Tokyo, Japan)
略  称:Intern Med
ISSNコード:13497235/09182918
掲載区分国外
巻・号・頁 57(1),65-70頁
著者・共著者 Tanaka Kenichi, Okada Yosuke, Mori Hiroko, Torimoto Keiichi, Arao Tadashi, Tanaka Yoshiya
発行年月 2018/04
概要 One adverse effect of methylprednisolone (MP) pulse therapy is an acute dose-dependent increase in the blood glucose level. Five patients with thyroid ophthalmopathy but normal glucose tolerance received MP pulse therapy (3 cycles, 3 days/week) and were assessed by continuous glucose monitoring. Steroid therapy increased the mean sensor glucose level, and all patients developed steroid-induced diabetes. The patients were treated alternately with mitiglinide (30 mg/day) and repaglinide (1.5 mg/day) during the second or third MP pulse therapy. The sensor glucose levels before lunch and dinner were more favorable during treatment with repaglinide than during treatment with mitiglinide. Repaglinide may be more clinically appropriate than mitiglinide.
DOI 10.2169/internalmedicine.9013-17
PMID 29021480