オカダ ヨウスケ   Okada Yosuke
  岡田 洋右
   所属   医学部医学科  臨床医学系 第1内科学
   職種   准教授
論文種別 症例報告
言語種別 英語
査読の有無 査読なし
表題 Two Sisters with Graves' Disease and Similar Clinical Features who Tested Positive for Anti-insulin Antibodies after Thiamazole Treatment.
掲載誌名 正式名:Internal medicine (Tokyo, Japan)
略  称:Intern Med
ISSNコード:13497235/09182918
巻・号・頁 55(9),1125-9頁
著者・共著者 Torimoto Keiichi, Okada Yosuke, Mori Hiroko, Tanaka Yoshiya
発行年月 2016
概要 The older of a pair of sisters experienced hypoglycemia after the start of thiamazole (MMI) treatment. Based on a high insulin antibody level, she was diagnosed with insulin autoimmune syndrome (IAS). HLA-DNA typing identified DRB1*04:06. Although a 75-g oral glucose tolerance test (OGTT) showed biphasic insulin secretion, the secretion pattern became monophasic after discontinuation of the MMI. The younger sister was diagnosed with IAS after the start of MMI treatment. HLA-DNA typing identified DRB1*04:06. The 75-g OGTT showed biphasic insulin secretion, but it became monophasic after discontinuation of the MMI. According to the similar insulin secretion kinetics in the two sisters with IAS, we suspect that a genetic predisposition may be associated with the features of anti-insulin antibodies.
DOI 10.2169/internalmedicine.55.6024
PMID 27150866