Azuma Kagaku
   Department   School of Medicine  Anatomy(1), Biomedical Sciences
Article types journal article
Language English
Peer review Peer reviewed
Title Microstructure of osteophytes in medial knee osteoarthritis.
Journal Formal name:Clinical rheumatology
Abbreviation:Clin Rheumatol
ISSN code:14349949/07703198
Domestic / ForeginForegin
Volume, Issue, Page 37(10),2893-2896頁
Author and coauthor Kizaki Kazuha, Uchida Soshi, Yamashita Fumiharu, Tsukamoto Manabu, Azuma Kagaku
Publication date 2018/10
Summary Knee osteoarthritis (OA) is one of the most common musculoskeletal diseases and osteophytes area frequent radiographic feature of knee OA. The osteophyte structure in knee OA, however, is not well elucidated. This study aimed to clarify the three-dimensional microstructural characteristics of osteophytes in the medial compartment of the knee in knee OA patients using micro-computed tomography (micro-CT). We hypothesized that the morphology of osteophytes would differ from that of the neighboring normal cancellous bones. Ten medial compartment knee OA patients with Kellgren-Lawrence grade 4 severity were enrolled in the study, and all patients underwent total knee arthroplasty. Osteophytes and cancellous bones were obtained from the medial femoral condyle. The three-dimensional trabecular bone microstructure was analyzed by quantitative micro-CT using image analysis software. The trabecular bone volume fraction and trabecular number were significantly lower in osteophytes than in cancellous bones. Consistently, trabecular separation was significantly higher in osteophytes. Osteophytes exhibited disorganized trabecular orientation, trabecular perforation, disruption, and complete disconnection. These findings suggest that osteophytes are functionally fragile.
DOI 10.1007/s10067-018-4262-4
PMID 30117009