Azuma Kagaku
   Department   School of Medicine  Anatomy(1), Biomedical Sciences
Article types review
Language English
Peer review Peer reviewed
Title Morphological and molecular characterization of the senile osteoporosis in senescence-accelerated mouse prone 6 (SAMP6).
Journal Formal name:Medical molecular morphology
Abbreviation:Med Mol Morphol
ISSN code:18601499/18601499
Domestic / ForeginForegin
Volume, Issue, Page 51(3),139-146頁
Author and coauthor Azuma Kagaku, Zhou Qian, Kubo Kin-Ya
Publication date 2018/04
Summary Although the understanding of the complex pathogenesis for osteoporosis is appreciable, the underlying mechanism is not yet fully elucidated. There is a great need to further characterize the available animal models in osteoporosis research. The senescence-accelerated mouse prone 6 (SAMP6) mice have been developed as the spontaneous experimental model for senile osteoporosis. Here, we provide a comprehensive overview of current research regarding the bone morphological and molecular alterations and the possible mechanisms involved in these changes. There were significant decrease in trabecular bone mass at the axial and appendicular skeletal sites, with no marked alterations of cortical bone. Decreased bone formation on the endosteal surface and trabecular bone, and increased bone marrow adiposity were observed in SAMP6 mice. The elevated expression level of proliferator activator gamma (PPARγ) in the bone marrow suggest that PPARγ might regulate osteoblastic bone formation negatively in SAMP6 mice. The expression level of secreted frizzled-related protein 4 (Sfrp4) was found to be higher in SAMP6 mice. Sfrp4 is considered to suppress osteoblastic proliferation mediated by inhibition of Wnt signaling pathway. These findings may help us to gain more insight into the potential mechanism of senile osteoporosis.
DOI 10.1007/s00795-018-0188-9
PMID 29619545