Azuma Kagaku
   Department   School of Medicine  Anatomy(1), Biomedical Sciences
Article types journal article
Language English
Peer review Peer reviewed
Title Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring.
Journal Formal name:International journal of medical sciences
Abbreviation:Int J Med Sci
ISSN code:14491907/14491907
Domestic / ForeginForegin
Volume, Issue, Page 14(4),348-355頁
Author and coauthor Azuma Kagaku, Ogura Minori, Kondo Hiroko, Suzuki Ayumi, Hayashi Sakurako, Iinuma Mitsuo, Onozuka Minoru, Kubo Kin-Ya
Publication date 2017/04
Summary Chronic psychological stress is a risk factor for osteoporosis. Maternal active mastication during prenatal stress attenuates stress response. The aim of this study is to test the hypothesis that maternal active mastication influences the effect of prenatal stress on bone mass and bone microstructure in adult offspring. Pregnant ddY mice were randomly divided into control, stress, and stress/chewing groups. Mice in the stress and stress/chewing groups were placed in a ventilated restraint tube for 45 minutes, 3 times a day, and was initiated on day 12 of gestation and continued until delivery. Mice in the stress/chewing group were allowed to chew a wooden stick during the restraint stress period. The bone response of 5-month-old male offspring was evaluated using quantitative micro-CT, bone histomorphometry, and biochemical markers. Prenatal stress resulted in significant decrease of trabecular bone mass in both vertebra and distal femur of the offspring. Maternal active mastication during prenatal stress attenuated the reduced bone formation and increased bone resorption, improved the lower trabecular bone volume and bone microstructural deterioration induced by prenatal stress in the offspring. These findings indicate that maternal active mastication during prenatal stress can ameliorate prenatal stress-induced lower bone mass of the vertebra and femur in adult offspring. Active mastication during prenatal stress in dams could be an effective coping strategy to prevent lower bone mass in their offspring.
DOI 10.7150/ijms.18298
PMID 28553167