Azuma Kagaku
   Department   School of Medicine  Anatomy(1), Biomedical Sciences
Article types journal article
Language English
Peer review Peer reviewed
Title Effects of Active Mastication on Chronic Stress-Induced Bone Loss in Mice.
Journal Formal name:International journal of medical sciences
Abbreviation:Int J Med Sci
ISSN code:14491907/14491907
Volume, Issue, Page 12(12),952-957頁
Author and coauthor Azuma Kagaku, Furuzawa Manabu, Fujiwara Shu, Yamada Kumiko, Kubo Kin-ya
Publication date 2015/11
Summary Chronic psychologic stress increases corticosterone levels, which decreases bone density. Active mastication or chewing attenuates stress-induced increases in corticosterone. We evaluated whether active mastication attenuates chronic stress-induced bone loss in mice. Male C57BL/6 (B6) mice were randomly divided into control, stress, and stress/chewing groups. Stress was induced by placing mice in a ventilated restraint tube (60 min, 2x/day, 4 weeks). The stress/chewing group was given a wooden stick to chew during the experimental period. Quantitative micro-computed tomography, histologic analysis, and biochemical markers were used to evaluate the bone response. The stress/chewing group exhibited significantly attenuated stress-induced increases in serum corticosterone levels, suppressed bone formation, enhanced bone resorption, and decreased trabecular bone mass in the vertebrae and distal femurs, compared with mice in the stress group. Active mastication during exposure to chronic stress alleviated chronic stress-induced bone density loss in B6 mice. Active mastication during chronic psychologic stress may thus be an effective strategy to prevent and/or treat chronic stress-related osteopenia.
DOI 10.7150/ijms.13298
PMID 26664256