Kagami Seiji
   Department   School of Medicine  Obstetrics and Gynecology, Clinical Medical Sciences
Article types journal article
Language English
Peer review Peer reviewed
Title 17β-Estradiol induces proliferation of endometrial NK cells (CD56+) in postmenopausal women.
Journal Formal name:Climacteric : the journal of the International Menopause Society
ISSN code:14730804/13697137
Domestic / ForeginForegin
Volume, Issue, Page 20(6),571-576頁
Author and coauthor Sho Tomoko, Hachisuga Toru, Koi Chiho, Kurita Tomoko, Kagami Seiji, Kawagoe Toshinori, Matsuura Yusuke, Yoshimura Kazuaki, Hisaoka Masanori
Publication date 2017/12
Summary OBJECTIVE:The aim of this report was to evaluate the impact of hormone replacement therapy (HRT) on lymphocytic infiltration of the endometrium in postmenopausal women.METHOD:This study included 58 Japanese patients who had undergone hysterectomy at the University Hospital of Occupational and Environmental Health, Japan. Before surgery, nine patients had received 17β-estradiol (E2), 0.72 mg transdermally for 2-8 weeks (E2 group); 16 patients had received an Estra-1,3,5(10)-triene-3,16α, 17β-triol (E3) vaginal tablet 0.5 mg per month five times (E3 group); and 19 patients had received 17β-estradiol, 0.62 mg, and norethindrone acetate (P), 2.70 mg for 3-16 weeks (E2 + P group). Fourteen patients received no HRT (control group). We examined uterine tissue specimens immunohistochemically for CD45+, CD3+, CD4+, CD8+, CD20+, CD56+, and Ki67 antigen-positive cells.RESULTS:The numbers of CD56 + cells were significantly increased in the E2 group compared with all other groups (E2 vs. E3: 7.0 vs. 0.75, p = 0.017; E2 vs. E2 + P: 7.0 vs. 0.58, p = 0.009; E2 vs.CONTROL:7.0 vs. 0.43, p = 0.010). The numbers of CD3+ cells were significantly increased in the E2 group compared with the control group (149.3 vs. 42.6, p = 0.008).CONCLUSION:17β-Estradiol induced the proliferation of endometrial uterine natural killer cells (CD56+) in postmenopausal women.
DOI 10.1080/13697137.2017.1377173
PMID 28933961