Ueda Taeko
   Department   School of Medicine  Obstetrics and Gynecology, Clinical Medical Sciences
Article types journal article
Language English
Peer review Peer reviewed
Title Clinical significance of cell-free and concentrated ascites re-infusion therapy for advanced and recurrent gynecological cancer.
Journal Formal name:Anticancer research
Abbreviation:Anticancer Res
ISSN code:17917530/02507005
Domestic / ForeginForegin
Volume, Issue, Page 32(6),2353-2357頁
Author and coauthor Ueda Taeko, Maehara Miyako, Takahashi Yoko, Nakayama Naomi, Kondo Haruhiko, Shirota Kyoko, Yoshizato Toshiyuki, Miyamoto Shingo
Publication date 2012/06
Summary BACKGROUND:The management of malignant ascites is critical for the treatment of patients with advanced gynecological cancer. The purpose of this study was to assess the clinical significance of cell-free and concentrated ascites re-infusion therapy (CART).PATIENTS AND METHODS:Adverse events, alterations in Eastern Cooperative Oncology Group performance status, serum albumin, body weight and abdominal circumference, and overall survival were examined in 22 patients with advanced gynecological cancer which were treated with CART.RESULTS:Most of the adverse events were grade 1 or 2 fever. CART treatment had little effect on ECOG performance status and on levels of serum albumin. There was a significant decrease in body weight and in abdominal circumference post-treatment with CART, relative to pre-treatment (p<0.01). The overall survival rate was significantly prolonged in 14 patients after CART plus chemotherapy, as compared with eight patients after CART alone (p<0.01).CONCLUSION:CART may contribute to the improvement of quality of life and of survival in patients with advanced gynecological cancer.
PMID 22641674