Ueda Taeko
   Department   School of Medicine  Obstetrics and Gynecology, Clinical Medical Sciences
Article types journal article
Language English
Peer review Peer reviewed
Title Monitoring of endometrial K-ras mutation in tamoxifen-treated patients with breast cancer.
Journal Formal name:International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Abbreviation:Int J Gynecol Cancer
ISSN code:15251438/1048891X
Domestic / ForeginForegin
Volume, Issue, Page 19(6),1052-1056頁
Author and coauthor Tsujioka Hiroshi, Hachisuga Toru, Fukuoka Miyoko, Ueda Taeko, Miyahara Daisuke, Horiuchi Shinji, Shirota Kyoko, Yoshizato Toshiyuki, Emoto Makoto, Miyamoto Shingo, Kawarabayashi Tatsuhiko
Publication date 2009/08
Summary INTRODUCTION:A high incidence of endometrial K-ras mutations has been reported in tamoxifen (TAM)-treated patients with breast cancer. We examined the changes in the frequency of the endometrial K-ras mutations after the cessation of TAM treatment.METHODS:DNA was extracted from fresh cytological or polypectomy samples of the endometrium in 28 patients who had undergone TAM treatment of breast cancer. Mutations were detected by an enriched polymerase chain reaction-enzyme-linked minisequence assay (Sumitomo Metal Industry, Inc, Tokyo, Japan). K-ras codon 12 mutations were monitored in these 28 patients.RESULTS:An initial examination detected endometrial K-ras mutations in 13 of the 28 patients. However, repeated examinations performed after cessation of TAM treatment did not detect endometrial K-ras mutations in any of these 13 patients. No endometrial K-ras mutation has been detected in the repeated examinations performed for these patients for more than 2 years since the cessation of TAM treatment. In addition, the 15 patients who did not have endometrial K-ras mutations in the initial examination did not demonstrate them in repeat examinations.CONCLUSIONS:The cessation of TAM treatment may reduce the risk of developing endometrial cancers through K-ras mutations.
DOI 10.1111/IGC.0b013e3181a8b0aa
PMID 19820367