モリタ ヒロミ
  守田 弘美
   所属   産業医科大学病院  診療科 小児科
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated with ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group
掲載誌名 正式名:Journal of clinical oncology : official journal of the American Society of Clinical Oncology
略  称:J Clin Oncol
ISSNコード:0732183X/15277755
掲載区分国外
巻・号・頁 36(9),900-7頁
著者・共著者 ◎Sakamoto Kenichi, Imamura Toshihiko, Kihira Kentaro, Ishida Hisashi, Suzuki Kouji, Morita Hiromi, Miyako Kanno, Mori Takeshi, Hiramatsu Hidefumi, Matsubara Kousaku, Terui Kiminori, Takahashi Yoshihiro, Suenobu So-ichi, Hasegawa Daiichiro, Kosaka Yoshiyuki, Kato Koji, Akiko Saito-Moriya, Sato Atsushi, Kawasaki Hirohide, Yumura Yagi Keiko, Hara Jun-ichi, Hori Hiroki, Horibe Keizo
発行年月 2018/03
概要 Purpose


Osteonecrosis (ON) is a serious complication of the treatment of childhood acute lymphoblastic leukemia (ALL); however, data relating to ON in Asian pediatric patients with ALL are scarce. Therefore, we performed a retrospective analysis of cohorts of Japanese patients with ALL to clarify the incidence, clinical characteristics, and risk factors of ON.



Patients and Methods


The incidence and characteristics of ON were determined in patients with ALL (n = 1,662) enrolled in two studies from the Japan Association of Childhood Leukemia Study (JACLS) group (n = 635 and n = 1,027 patients treated with the ALL-97 and ALL-02 protocols, respectively).



Results


In total, 24 of 1,662 patients suffered from ON, of which 12 of 635 and 12 of 1,027 patients were treated with the ALL-97 and the ALL-02 protocol, respectively. Of the 24 patients, 23 were older than 10 years. In multivariate analysis, age (≥ 10 years) was the sole significant risk factor for ON (P < .001). Separate evaluation of patients ≥ 10 years of age indicated a 5-year cumulative incidence of ON of 7.2% (95% CI, 4.0% to 12.6%) and 5.9% (95% CI, 3.3% to 10.4%) in the ALL-97 and the ALL-02 protocol, respectively, which was lower than reported previously, despite an administration of dexamethasone (DEX) similar to that in comparable studies; however, concomitant administration of DEX and l-asparaginase was reduced in the JACLS protocols.


Conclusion


We identified a low frequency of ON in the JACLS ALL-97 and ALL-02 studies. Although the sole risk factor for ON was age (≥ 10 years), even among high-risk patients, ON incidence was significantly lower than that reported in previous studies. These results suggest that, not only the total amount of DEX, but also how DEX and l-asparaginase are administered, which affects the clearance of DEX, may be associated with ON incidence in patients with ALL.
DOI 10.1200/JCO.2017.75.5066
PMID 29360413