ツジ マユミ   Tsuji Mayumi
  辻 真弓
   所属   医学部医学科  基礎医学系 衛生学
   職種   教授
論文種別 不明
言語種別
査読の有無 査読なし
表題 Impact of sleep duration during pregnancy on the risk of gestational diabetes in the Japan environmental and Children's study (JECS).
掲載誌名 正式名:BMC pregnancy and childbirth
略  称:BMC Pregnancy Childbirth
ISSNコード:14712393/14712393
巻・号・頁 19(1),483頁
著者・共著者 Myoga Mai, Tsuji Mayumi, Tanaka Rie, Shibata Eiji, Askew David J, Aiko Yukiyo, Senju Ayako, Kawamoto Toshihiro, Hachisuga Toru, Araki Shunsuke, Kusuhara Koichi, Morokuma Seiichi, Sanefuji Masafumi,
発行年月 2019/12
概要 BACKGROUND:Gestational diabetes mellitus (GDM) has serious effects on both mother and child. Like Type 2 Diabetes Mellitus, it is increasing in prevalence world-wide. In addition to obesity, sleep duration has been named an important risk factor. Using a large cohort study, including data from 48,787 participants of the Japan Environment and Children's Study (JECS), we examined the association between sleep duration and both random blood glucose levels and GDM rates during pregnancy.METHODS:Random blood glucose levels were measured during pregnancy. GDM diagnosis was based on the results of 75 g oral glucose tolerance test. Additional anthropometric data was collected from questionnaires for statistical analysis.RESULTS:Compared to mothers averaging 7 to < 10 h sleep (reference group), women receiving < 5 h or ≥ 10 h sleep exhibited significantly elevated random blood glucose levels. This was associated with an elevated risk for positive GDM screening (< 5 h sleep: OR 1.17 (0.96-1.44) p = 0.126; ≥10 h sleep: OR 1.13 (1.03-1.25) p = 0.006). Calculating the risk for GDM, women sleeping < 5 h or ≥ 10 h exhibited elevated risks of 1.31-fold and 1.21 respectively. However, this trend was not found to be significant.CONCLUSIONS:Sleep is a critical factor in glucose metabolism, with both abnormally long and short sleep duration increasing random blood glucose levels in pregnant women. Moreover, the risk for positive GDM screening increases significantly with elevated sleep, ≥10 h per night. These findings are promising because they support the idea that sleep duration is a modifiable risk factor, and can be focused upon to improve health and pregnancy outcome.
DOI 10.1186/s12884-019-2632-9
PMID 31818260