ツジ マユミ   Tsuji Mayumi
  辻 真弓
   所属   医学部医学科  基礎医学系 衛生学
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study.
掲載誌名 正式名:Journal of epidemiology
略  称:J Epidemiol
ISSNコード:13499092/09175040
掲載区分国外
巻・号・頁 29(12),478-486頁
著者・共著者 Tsuji Mayumi, Koriyama Chihaya, Ishihara Yasuhiro, Yamamoto Megumi, Yamamoto-Hanada Kiwako, Kanatani Kumiko, Bamai Yu Ait, Onishi Kazunari, Senju Ayako, Araki Shunsuke, Shibata Eiji, Morokuma Seiichi, Sanefuji Masafumi, Kitazawa Hiroshi, Saito Mayako, Umezawa Masakazu, Onoda Atsuto, Kusuhara Koichi, Tanaka Rie, Kawamoto Toshihiro,
発行年月 2019/12
概要 BACKGROUND:Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.METHODS:We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children's Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second/third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ≥0.35 UA/mL, and the metal levels were divided into quartiles.RESULTS:Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.CONCLUSIONS:Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.
DOI 10.2188/jea.JE20180098
PMID 30643099