Imanishi Naoko
   Department   University Hospital  General Thoracic Surgery, Clinical Departments
Article types journal article
Language English
Peer review Peer reviewed
Title A liquid biopsy in primary lung cancer
Journal Formal name:Surgery today (Tokyo, Japan)
Abbreviation:Surg Today.
ISSN code:09411291
Domestic / ForeginForegin
Publisher Surgery Today
Volume, Issue, Page 49(1),1-14頁
Author and coauthor Kazue Yoneda,Naoko Imanishi,Yoshinobu Ichiki,Fumihiro Tanaka
Publication date 2019/01
Summary Abstract
A tissue biopsy is the "golden standard" for molecular profiling that is essential in decision-making regarding treatment for malignant tumors, including primary lung cancer. However, tumor biopsies are associated with several limitations, including invasiveness and difficulty in achieving access. Liquid biopsies have several potential advantages over tissue biopsies, and recent advances in molecular technologies have enabled liquid biopsies to be introduced into daily clinical practice. Cell-free blood-based liquid biopsies to detect mutations in the epidermal growth factor receptor (EGFR) gene in the plasma have been approved and may be useful in selecting patients for treatment with tyrosine kinase inhibitors of EGFR. We herein describe blood-based liquid biopsies and review the current status and future perspectives of plasma genotyping in primary lung cancer.
DOI 10.1007/s00595-018-1659-2
PMID 29644440