Imanishi Naoko
   Department   University Hospital  General Thoracic Surgery, Clinical Departments
Article types case reports
Language English
Peer review Peer reviewed
Title Complete resection for pleomorphic lung cancer with a high serum IL-6 level: a case report.
Journal Formal name:Surgical case reports
Abbreviation:Surg Case Rep
ISSN code:/21987793
Domestic / ForeginForegin
Volume, Issue, Page 2(1),101頁
Author and coauthor Oka Soichi, Matsumiya Hiroki, Shinohara Shuichi, Kuwata Taiji, Takenaka Masaru, Chikaishi Yasuhiro, Hirai Ayako, Imanishi Naoko, Kuroda Koji, Uramoto Hidetaka, Tanaka Fumihiro
Publication date 2016/12
Summary BACKGROUND:Pleomorphic lung cancer cells have been reported to produce cytokines, resulting in systemic reactions. Recently, the autonomous production of hematopoietic cytokines (granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor [GM-CSF], and interleukin-6 [IL-6]) was observed in some of these patients.CASE PRESENTATION:We herein report a case of complete resection of right pleomorphic lung cancer producing IL-6. The patient had a high-grade fever before surgery, and a blood examination showed high IL-6 and CRP levels in the serum. After surgery, the patient no longer had a fever, and the elevated serum IL-6 levels had dropped to values less than those before the operation. Immunohistochemically, the carcinoma cells were faintly or focally positive for IL-6 and negative for G-CSF.CONCLUSIONS:The symptoms in the present case were dramatically improved by surgery. In addition, an immunohistochemical examination showed that the cancer cells were positive for IL-6.
DOI 10.1186/s40792-016-0232-8
PMID 27659803