Nakano Yoshiteru
   Department   School of Medicine  Neurosurgery, Clinical Medical Sciences
Article types journal article
Language English
Peer review Peer reviewed
Title Effects of 1-bromopropane, a substitute for chlorofluorocarbons, on BDNF expression.
Journal Formal name:International immunopharmacology
Abbreviation:Int Immunopharmacol
ISSN code:18781705/15675769
Volume, Issue, Page 9(4),433-8頁
Author and coauthor Yoshida Yasuhiro, Nakano Yoshiteru, Ueno Susumu, Liu Jiqin, Fueta Yukiko, Ishidao Toru, Kunugita Naoki, Yanagihara Nobuyuki, Sugiura Tsutomu, Hori Hajime, Yamashita Uki
Publication date 2009/04
Summary 1-Bromopropane (1-BP) has been widely used as an alternative to ozone-depleting chlorofluorocarbons in various industries. Although the neurotoxicity of 1-BP has been recently reported, there is little information about the effect of 1-BP on the cells in brain by experimental approach. Here we studied the effect of 1-BP on brain-derived neurotrophic factor (BDNF) expression in astrocytes in vitro. The BDNF mRNA level was remarkably decreased by 1-BP in a human astrocytoma cell line, U251, and in mouse primary astrocytes. The DNA-binding and specific reporter activity of cAMP response element-binding transcription factor (CREB), which is one of the key molecules regulating BDNF expression, were reduced by 1-BP in U251 and/or mouse primary astrocytes. Additionally, protein kinase A (PKA) activity was suppressed by 1-BP in U251. These results suggest that BDNF expression was affected by 1-BP through at least PKA.
DOI 10.1016/j.intimp.2009.01.007
PMID 19189864