Nakano Yoshiteru
   Department   School of Medicine  Neurosurgery, Clinical Medical Sciences
Article types case reports
Language English
Peer review Peer reviewed
Title Multiple intracranial nodules associated with rheumatoid arthritis: case report.
Journal Formal name:Neurologia medico-chirurgica
Abbreviation:Neurol Med Chir (Tokyo)
ISSN code:13498029/04708105
Volume, Issue, Page 54(4),317-20頁
Author and coauthor Takahashi Mayu, Yamamoto Junkoh, Idei Masaru, Nakano Yoshiteru, Soejima Yoshiteru, Saito Takeshi, Akiba Daisuke, Nishizawa Shigeru
Publication date 2014/04
Summary A 71-year-old woman with active rheumatoid arthritis (RA) was referred to our department because of multiple intracranial nodules. On admission, the RA disease activity was very high even after the treatment of methotrexate in other hospital. She underwent open biopsy to confirm a histopathological diagnosis of the intracranial lesions. Surgical specimen mainly consisted of necrosis surrounded by epithelioid cells. The masses were reduced spontaneously in size without additional treatment. Eleven month later, the lesions were relapsed. She underwent treatment with corticosteroid, and the lesions were remarkably regressed. The clinical course and histological examination were compatible with rheumatoid nodule (RN). Intracranial RN is extremely rare and its clinical course is not completely understood. In active RA patients, RNs should be considered, and histological diagnosis is inevitable for following suitable treatment.
PMID 24140764