Hori Hikaru
   Department   School of Medicine  Psychiatry, Clinical Medical Sciences
Article types journal article
Language English
Peer review Peer reviewed
Title Relationship between the hippocampal shape abnormality and serum cortisol levels in first-episode and drug-naïve major depressive disorder patients.
Journal Formal name:Depression and anxiety
Abbreviation:Depress Anxiety
ISSN code:15206394/10914269
Domestic / ForeginForegin
Volume, Issue, Page 34(5),401-409頁
Author and coauthor Watanabe Rieko, Kakeda Shingo, Watanabe Keita, Liu Xiaodan, Katsuki Asuka, Umeno-Nakano Wakako, Hori Hikaru, Abe Osamu, Yoshimura Reiji, Korogi Yukunori
Publication date 2017/05
Summary BACKGROUND:We aimed to investigate the relationship between the hippocampal shape deformations and the serum cortisol levels in first-episode and drug-naïve major depression disorder (MDD) patients.METHODS:Thirty first-episode and drug-naïve MDD patients and 40 healthy subjects were recruited. High-resolution T1-weighted imaging and morning blood samples for cortisol measurement were obtained from all MDD patients and healthy subjects. In the hippocampal shape analysis, we compared the hippocampal shape between MDD patients and healthy subjects and evaluated the linear correlation between hippocampal shape deformations and the serum cortisol levels in MDD patients and healthy subjects.RESULTS:MDD patients showed significant inward deformations predominantly in the cornu ammonis (CA) 1 and subiculum in bilateral hippocampi compared to healthy subjects (false discovery rate (FDR) corrected, P < .05). Furthermore, in MDD patients, a significant linear correlation between inward deformations and high cortisol levels were found predominantly in the CA1 and subiculum, extending into the CA2-3 (FDR-corrected, P < .05), whereas no significant linear correlation was observed in healthy subjects.CONCLUSIONS:The serum cortisol levels are therefore considered to be associated with hippocampal shape abnormalities in MDD.
DOI 10.1002/da.22604
PMID 28129464