Hori Hikaru
   Department   School of Medicine  Psychiatry, Clinical Medical Sciences
   Position  
Article types journal article
Language English
Peer review Peer reviewed
Presence of invitation Invited paper
Title Blood Biomarkers Predict the Cognitive Effects of Aripiprazole in Patients with Acute Schizophrenia.
Journal Formal name:International journal of molecular sciences
Abbreviation:Int J Mol Sci
ISSN code:14220067/14220067
Domestic / ForeginForegin
Volume, Issue, Page 18(3),1-8頁
Author and coauthor Hori Hikaru, Yoshimura Reiji, Katsuki Asuka, Atake Kiyokazu, Igata Ryohei, Konishi Yuki, Beppu Hiroki, Tominaga Hirotaka
Publication date 2017/03
Summary Aripiprazole has been reported to exert variable effects on cognitive function in patients with schizophrenia. Therefore, in the present study, we evaluated biological markers, clinical data, and psychiatric symptoms in order to identify factors that influence cognitive function in patients with schizophrenia undergoing aripiprazole treatment. We evaluated cognitive function in 51 patients with schizophrenia using Brief Assessment of Cognition in Schizophrenia (BACS), as well as background information, psychiatric symptoms, plasma catecholamine metabolites-homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG)-, and serum brain-derived neurotrophic factor (BDNF). Multivariate analyses were performed in order to identify factors independently associated with cognitive function. Brain-derived neurotrophic factor levels, number of hospitalizations, and MHPG levels were associated with verbal memory and learning. Total hospitalization period and MHPG levels were associated with working memory. Age at first hospitalization and education were associated with motor speed. The number of hospital admissions, Positive and Negative Syndrome Scale negative subscale scores (PANSS-N), MHPG levels, BDNF levels, and Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS) scores were associated with verbal fluency. Homovanillic acid and MHPG levels, duration of illness, and PANSS-N scores were associated with attention and processing speed. Brain-derived neurotrophic factor and MHPG levels were associated with executive function. These results suggest that treatment of psychiatric symptoms and cognitive dysfunction may be improved in patients treated with aripiprazole by controlling for these contributing factors.
DOI 10.3390/ijms18030568
PMID 28272307