Hori Hikaru
   Department   School of Medicine  Psychiatry, Clinical Medical Sciences
   Position  
Article types journal article
Language English
Peer review Peer reviewed
Title Serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol levels in chronic schizophrenia.
Journal Formal name:Annals of general psychiatry
Abbreviation:Ann Gen Psychiatry
ISSN code:/1744859X
Domestic / ForeginForegin
Volume, Issue, Page 15,1頁
Author and coauthor Yoshimura Reiji, Hori Hikaru, Katsuki Asuka, Atake Kiyokazu, Nakamura Jun
Publication date 2016
Summary BACKGROUND:We investigated the serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in patients with chronic schizophrenia.METHODS:Sixty-eight patients who met the DSM-IV-TR criteria and had a chronic schizophrenia (CS) duration of ≥ 5 years were enrolled. Their serum brain-derived BDNF and proBDNF levels were measured by enzyme-linked immunosorbent assays, and their plasma MHPG levels were analyzed by high-performance liquid chromatography with electrochemical detection.RESULTS:The plasma MHPG levels were significantly lower in the CS group (3.9  ±  1.8 ng/ml) compared to those in the group of 32 age- and sex-matched healthy controls (5.1  ±  2.4 ng/ml). The serum BDNF levels were significantly lower in the CS group (8.9  ±  4.8 ng/ml) compared to the control group (12.2.1  ±  6.8 ng/ml). No correlation was observed between plasma MHPG and BDNF in the CS group.CONCLUSION:These results suggest that hypo-activity of noradrenergic neurons and decreased BDNF secretion exist in chronic schizophrenic patients.
DOI 10.1186/s12991-015-0084-9
PMID 26770258