Matsumoto Masahiro
   Department   School of Medicine  Urology, Clinical Medical Sciences
   Position  
Article types 不明
Language English
Peer review Non peer reviewed
Title Occurrence of infection following prostate biopsy procedures in Japan: Japanese Research Group for Urinary Tract Infection (JRGU) - a multi-center retrospective study.
Journal Formal name:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Abbreviation:J Infect Chemother
ISSN code:14377780/1341321X
Domestic / ForeginForegin
Volume, Issue, Page 20(4),232-7頁
Author and coauthor Togo Yoshikazu, Kubo Tatsuhiko, Taoka Rikiya, Hiyama Yoshiki, Uehara Teruhisa, Hashimoto Jiroh, Kurimura Yuichiro, Takahashi Satoshi, Tsukamoto Taiji, Miyazaki Jun, Nishiyama Hiroyuki, Kira Shinichiro, Kiyota Hiroshi, Yazawa Satoshi, Niwa Naoya, Hongo Hiroshi, Oya Mototsugu, Kato Taku, Yasuda Mitsuru, Deguchi Takashi, Ishikawa Kiyohito, Hoshinaga Kiyotaka, Matsumoto Minori, Shigemura Katsumi, Tanaka Kazushi, Arakawa Soichi, Fujisawa Masato, Wada Koichiro, Uehara Shinya, Watanabe Toyohiko, Kumon Hiromi, Kobayashi Kanao, Matsubara Akio, Matsumoto Masahiro, Sho Takehiko, Hamasuna Ryoichi, Matsumoto Tetsuro, Hayami Hiroshi, Nakagawa Masayuki, Yamamoto Shingo
Publication date 2014/04
Summary We retrospectively investigated the incidence of genitourinary tract infection in 5895 patients who underwent transrectal and/or transperineal prostate biopsy procedure between January and December 2011 at 46 institutions belonging to Japanese Research Group for Urinary Tract Infection (JRGU). The total rate of genitourinary tract infection after prostate biopsy was 0.76%, while that following transrectal procedure was 0.83% and following transperineal procedure was 0.57%, which were not significantly different. In contrast, febrile infection associated with a fever (≥38 °C) occurred significantly more frequently after transrectal (0.71%) than transperineal (0.16%) approach (P = 0.04). Notably, in infectious cases, Escherichia coli was most frequently isolated. Of the 9 E. coli strains isolated by urine culture, 6 (66.7%) produced extended spectrum β-lactamase (ESBL) and 7 (77.8%) showed levofloxacin resistance. Similarly, of 6 E. coli strains isolated by blood culture, 4 (66.7%) produced ESBL and 6 (100%) showed levofloxacin resistance. When the efficacy of antimicrobial prophylaxis (AMP) with levofloxacin for the patients undergoing transrectal or transperineal biopsy was compared between a single dose (500 mg) and that given for 2 or more days, no significant difference was observed for the rate of infection (transrectal: 0.82% vs. 1.04%, p = 0.94; transperineal: 0.30% vs. 0.46%, p = 0.68). Although a single dose of levofloxacin for AMP is sufficient to prevent genitourinary infection after transrectal or transperineal prostate biopsy, and recommended in this era of increased multi-drug resistant pathogens, the increase in fluoroquinolone-resistant E. coli and ESBL-producing E. coli has emerged as a profound problem for surveillance.
DOI 10.1016/j.jiac.2013.10.003
PMID 24594451