Minato Akinori
   Department   School of Medicine  Urology, Clinical Medical Sciences
Article types review
Language English
Peer review Peer reviewed
Title Gene Polymorphism-related Individual and Interracial Differences in the Outcomes of Androgen Deprivation Therapy for Prostate Cancer.
Journal Formal name:Clinical genitourinary cancer
Abbreviation:Clin Genitourin Cancer
ISSN code:19380682/15587673
Volume, Issue, Page 569-575頁
Author and coauthor Fujimoto Naohiro, Shiota Masaki, Tomisaki Ikko, Minato Akinori
Publication date 2017/01
Summary Among patients with prostate cancer, the prognosis after androgen deprivation therapy differs significantly among individuals and among races; however, the reasons underlying these differences are poorly understood. Several single nucleotide polymorphisms in genes associated with prostate cancer progression or castration resistance might serve as the host factor that influences prognosis and, thus, accounts for these individual and racial gaps in treatment outcomes. Accordingly, single nucleotide polymorphisms associated with treatment outcomes could be used as predictive and/or prognostic biomarkers for patient stratification and to identify personalized treatment and follow-up protocols. The present review has summarized the genetic polymorphisms that have been reported to associate with androgen deprivation therapy outcomes among patients with prostate cancer and compared the allele frequencies among different ethnic groups.
DOI 10.1016/j.clgc.2017.01.006
PMID 28188049