Koi Chiho
   Department   University Hospital  Obstetrics and Gynecology, Clinical Departments
Article types journal article
Language English
Peer review Peer reviewed
Title Expression of N-Acetylgalactosaminyltransferase-6 Is Related to Expression of Cell Adhesion Molecules in Endometrial Cancer.
Journal Formal name:Anticancer research
Abbreviation:Anticancer Res
ISSN code:17917530/02507005
Domestic / ForeginForegin
Publisher International Institute of Anticancer Research
Volume, Issue, Page 37(7),3905-3910頁
Author and coauthor Kurita Tomoko, Thi Thuy Nguyen, Koi Chiho, Murakami Midori, Kagami Seiji, Izumi Hiroto, Hachisuga Toru
Publication date 2017/07
Summary BACKGROUND:The aberrant glycosylation of mucin type O-glycans is thought to be associated with functional alteration of cancer cells, including adhesive properties, as well as their potential for invasion and metastasis. Positive expression of N-acetylgalactosaminyltransferase-6 (GalNAc-T6) may also be a marker for aberrant O-glycans in carcinogenesis. We previously reported that over-expression of GalNAc-T6 had a strong association with endometrial cell invasion ability in vitro.MATERIALS AND METHODS:This study investigated the relationship between GalNAc-T6 expression and cell adhesion molecules in 218 endometrial carcinomas by immunohistochemistry.RESULTS:Expression of GalNAc-T6 was found to be significantly related to expression of E-cadherin. Positive expression of GalNAc-T6 was significantly associated with better histological grade and good clinical prognosis of patients, but positive E-cadherin and β-catenin expression were not significantly associated with improved overall survival.CONCLUSION:GalNAc-T6 might be related to cell-cell adhesion in the early phase of cancer invasion in endometrial carcinoma.
DOI 10.21873/anticanres.11772
PMID 28668893