Koi Chiho
   Department   University Hospital  Obstetrics and Gynecology, Clinical Departments
   Position  
Article types journal article
Language English
Peer review Peer reviewed
Title GalNAc-T6 in the relationship with invasion ability of endometrial carcinomas and prognostic significance.
Journal Formal name:American journal of cancer research
Abbreviation:Am J Cancer Res
ISSN code:/21566976
Domestic / ForeginForegin
Publisher Century Publishing Corporation
Volume, Issue, Page 7(5),1188-1197頁
Author and coauthor Nguyen Thuy Thi, Kurita Tomoko, Koi Chiho, Murakami Midori, Kagami Seiji, Hachisuga Toru, Hisaoka Masanori, Morimoto Yasuo, Izumi Hiroto
Publication date 2017/05
Summary O-glycosylation in the field of carcinogenesis has been a critical topic of concern for several decades. The abnormal function of enzymes catalyzing the first step of this process, named polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts) has been determined to play an important role in cancer development and metastasis. Accordingly, we investigated the expression of GalNAc-T6 in endometrial carcinoma and evaluated the relationship between invasion characteristics and the cellular level of GalNAc-T6. The results suggested that positive GalNAc-T6 expression is significantly associated with histological grade of tumors and myometrial invasion characteristic. In vitro experiments showed that the over expression of GalNAc-T6 had strong association with the decrease of endometrial cell invasiveness. Taken together, our data support the use of GalNAc-T6 as a potential indicator of good prognosis and noninvasive tumor in patients with endometrial carcinoma.
PMID 28560066