Koi Chiho
   Department   University Hospital  Obstetrics and Gynecology, Clinical Departments
Article types journal article
Language English
Peer review Peer reviewed
Title Overexpression of p53 in the endometrial gland in postmenopausal women.
Journal Formal name:Menopause (New York, N.Y.)
ISSN code:15300374/10723714
Domestic / ForeginForegin
Volume, Issue, Page 22(1),104-107頁
Author and coauthor Koi Chiho, Hachisuga Toru, Murakami Midori, Kurita Tomoko, Nguyen Thuy Thi, Shimajiri Shohei, Fujino Yoshihisa
Publication date 2015/01
Summary OBJECTIVE:The p53 signature, which (although morphologically unremarkable) displays diffuse and strong p53 nuclear staining, has been proposed to be a precursor of serous endometrial intraepithelial carcinoma. We examined the overexpression of p53 in postmenopausal endometrial glands.METHODS:Postmenopausal endometrial tissues of 82 women with benign disease, including 10 hormone users, were evaluated in this study. Tissues with endometrial hyperplasia and/or polyps were excluded based on a histopathologic review. Expressions of estrogen receptor-α, Ki-67, and p53 were immunohistochemically examined. Apoptotic cells were identified using a terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Overexpression of p53 was categorized as moderate to strong in more than 50% of glandular cell nuclei.RESULTS:Focal glandular overexpression of p53 was observed in 1 (9%) of 10 and in 8 (11%) of 72 postmenopausal endometrial tissue specimens in women with and women without a history of hormone use, respectively. Among nonhormone users, the median Ki-67 and apoptotic indices in the postmenopausal endometrial glands of women with and women without overexpression of p53 were 16% and 6% (P = 0.007) and 1% and 1% (P = 0.345), respectively. All postmenopausal endometrial glands were positive for estrogen receptor-α, regardless of the overexpression of p53. The postmenopausal endometrial glands of estrogen users exhibited significantly higher Ki-67 and apoptotic indices than those of nonestrogen users (P = 0.001 and P < 0.001, respectively).CONCLUSIONS:Overexpression of p53 may be responsible for the high proliferative activity of postmenopausal endometrial glandular cells associated with conditions of low apoptotic cell death.
DOI 10.1097/GME.0000000000000265
PMID 24893067