オオタニ マコト   Otani Makoto
  大谷 誠
   所属   関連施設  産業保健データサイエンスセンター 産業保健データサイエンスセンター
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Effects of proton pump inhibitor on outcomes of patients with severe acute pancreatitis based on a national administrative database.
掲載誌名 正式名:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
略  称:Pancreatology
ISSNコード:14243911/14243903
巻・号・頁 15(5),491-6頁
著者・共著者 Murata Atsuhiko, Ohtani Makoto, Muramatsu Keiji, Matsuda Shinya
発行年月 2015
概要 OBJECTIVE:This study aimed to investigate whether proton pump inhibitors (PPIs) affect the outcomes of patients with severe acute pancreatitis based on a national administrative database.METHODS:A total of 10,400 patients with severe acute pancreatitis were referred to 1021 hospitals between 2010 and 2012 in Japan. Patients were divided into two groups: patients who used PPIs (n = 3879) and those without PPIs (n = 6521). We collected patients' data from the administrative database to compare in-hospital mortality within 7, 14, and 28 days, and overall in-hospital mortality between groups, using propensity score analysis to adjust for treatment selection bias.RESULTS:Multiple logistic regression showed that use of PPIs did not affect in-hospital mortality within 7 and 14 days. The odds ratio (OR) for mortality within 7 days was 1.14 (95% confidence interval [CI]: 0.91-1.42, p = 0.236) while that within 14 days was 1.10 (95% CI: 0.89-1.35, p = 0.349). No significant association was observed for in-hospital mortality within 28 days and overall in-hospital mortality (OR for within 28 days: 1.12, 95% CI: 0.92-1.37, p = 0.224; OR for overall in-hospital mortality: 1.42, 95% CI: 0.97-1.87, p = 0.065).CONCLUSIONS:This study shows that use of PPIs does not affect clinical outcomes of patients with severe acute pancreatitis. Prospective or randomized studies are needed to confirm the efficacy of PPIs on outcomes of patients with severe acute pancreatitis in the future.
DOI 10.1016/j.pan.2015.07.006
PMID 26296720