オオタニ マコト   Otani Makoto
  大谷 誠
   所属   関連施設  産業保健データサイエンスセンター 産業保健データサイエンスセンター
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Influence of comorbidity on outcomes of older patients with acute pancreatitis based on a national administrative database.
掲載誌名 正式名:Hepatobiliary & pancreatic diseases international : HBPD INT
略  称:Hepatobiliary Pancreat Dis Int
ISSNコード:14993872
巻・号・頁 14(4),422-8頁
著者・共著者 Murata Atsuhiko, Ohtani Makoto, Muramatsu Keiji, Matsuda Shinya
発行年月 2015/08
概要 BACKGROUND:Little information is available on the influence of comorbidities on outcomes of older patients with acute pancreatitis. This study aimed to investigate the influence of comorbidities on outcomes of older patients with acute pancreatitis using data from a national Japanese administrative database.METHODS:A total of 14 322 older patients (≥70 years) with acute pancreatitis were referred to 1090 hospitals between 2010 and 2012 in Japan. We collected patients' data from the administrative database to compare the in-hospital mortality and length of stay of older patients with acute pancreatitis. The patients were categorized into four groups according to comorbidity level using the Charlson Comorbidity Index (CCI): none (CCI score=0; n=6890); mild (1; n=3874); moderate (2; n=2192) and severe (≥3; n=1366).RESULTS:Multiple logistic and linear regression analyses revealed that severe comorbidity was significantly associated with higher in-hospital mortality and longer length of stay [odds ratio (OR)=2.26; 95% confidence interval (CI): 1.75-2.92, P<0.001 and coefficient 4.37 days; 95% CI: 2.89-5.85, P<0.001, respectively]. In addition, cardiovascular and renal diseases were the most significant comorbidities affecting outcomes of the older patients. ORs of cardiovascular and renal diseases for mortality were 1.44 (95% CI: 1.13-1.85, P=0.003) and 2.69 (95% CI: 1.88-3.85, P<0.001), respectively, and coefficients for length of stay were 3.01 days (95% CI: 1.34-4.67, P<0.001) and 3.72 days (95% CI: 1.01-6.42, P=0.007), respectively.CONCLUSION:This study demonstrated that comorbidities significantly influenced outcomes of older patients with acute pancreatitis and cardiovascular and renal comorbidities were significant factors affecting outcomes.
PMID 26256088