オオタニ マコト   Otani Makoto
  大谷 誠
   所属   関連施設  産業保健データサイエンスセンター 産業保健データサイエンスセンター
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読なし
表題 Coexisting infectious diseases on admission as a risk factor for mechanical ventilation in patients with Guillain-Barré syndrome.
掲載誌名 正式名:Journal of epidemiology
略  称:J Epidemiol
ISSNコード:13499092/09175040
巻・号・頁 S0917(17),30018頁
著者・共著者 Kobori Shinichiro, Kubo Tatsuhiko, Otani Makoto, Muramatsu Keiji, Fujino Yoshihisa, Adachi Hiroaki, Horiguchi Hiromasa, Fushimi Kiyohide, Matsuda Shinya
発行年月 2017/03
概要 BACKGROUND:The aim of this study was to investigate patient characteristics on admission to hospital that increase the risk of subsequent mechanical ventilation (MV) use for patients with Guillain-Barré syndrome (GBS).METHODS:We extracted data from the Japanese Diagnosis Procedure Combination (DPC) database for 4132 GBS patients admitted to hospital. Clinical characteristics of GBS patients with and without MV were compared. Multivariate logistic regression analyses were performed to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the associations of requirement for MV with coexisting infectious diseases, after adjustment for potential confounding variables, age, sex, hospital type, and ambulance transportation.RESULTS:In total, 281 patients required MV, and 493 patients had coexisting respiratory diseases on admission. After adjustment for covariates and stratification by coexisting respiratory diseases, multivariate logistic regression analysis revealed that coexisting cytomegaloviral (CMV) disease (OR 8.81; 95% CI, 2.34-33.1) and herpes simplex viral (HSV) infections (OR 4.83; 95% CI, 1.16-20.1) were significantly associated with the requirement for MV in the group without coexisting respiratory diseases.CONCLUSION:Our findings suggest that coexisting CMV and HSV infections on admission might be significantly associated with increased risk of respiratory failure in GBS patients.
DOI 10.1016/j.je.2016.07.003
PMID 28283417