エグチ マミ   Eguchi Mami
  江口 真美
   所属   産業医科大学病院  診療科 小児科
   職種   助教
論文種別 不明
言語種別
査読の有無 査読なし
表題 [Evaluation of Clinical Features and Growth Hormone Deficiency in Short Children Born Small For Gestational Age].
掲載誌名 正式名:Journal of UOEH
略  称:J UOEH
ISSNコード:0387821X/0387821X
巻・号・頁 40(3),253-257頁
著者・共著者 Ikegami Tomomi, Araki Shunsuke, Kuwamura Mami, Taku Aoi, Saito Reiko, Goto Motohide, Kubo Kazuyasu, Kawagoe Rinko, Yamamoto Yukiyo, Kawada Yasusada, Kusuhara Koichi
概要 Growth hormone (GH) therapy for short children born small for gestational age (SGA) has been approved in Japan. It is important to evaluate GH secretion ability before the initiation of GH therapy because there are some differences in dose and medical expenses between short children born SGA and GH deficiency (GHD). This study was designed to elucidate the incidence of GHD and to find a useful marker for detecting it in short SGA children. We retrospectively reviewed medical records to analyze the clinical features of short children born SGA and with GHD who had started GH therapy before the age of 6 in the University Hospital of Occupational and Environmental Health and Kyushu Rousai Hospital. Nine of 22 SGA subjects (41%) had GHD. There were no significant differences between two groups of short SGA children (GHD, non-GHD) in the median of height and serum insulin-like growth factors (IGF)-1 levels at birth or at the start of GH therapy. The probability of GHD was higher if the height standard deviation scores (SD) of the SGA children were lower than -3.2 (odds ratio, 11.6; 95% confidence interval, 1.52 - 89.1, P = 0.013). This study showed that there is an approximately 40% incidence of GHD in short SGA children needing GH treatment. We should do GH stimulation tests for short SGA children whose height SD is lower than -3 to determine the appropriate GH therapy.
DOI 10.7888/juoeh.40.253
PMID 30224622