エグチ マミ   Eguchi Mami
  江口 真美
   所属   産業医科大学病院  診療科 小児科
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Plasma but not serum brain-derived neurotrophic factor concentration is decreased by oral glucose tolerance test-induced hyperglycemia in children.
掲載誌名 正式名:Journal of pediatric endocrinology & metabolism : JPEM
略  称:J Pediatr Endocrinol Metab
ISSNコード:21910251/0334018X
掲載区分国外
巻・号・頁 30(5),525-530頁
著者・共著者 ◎Araki Shunsuke, Yamamoto Yukiyo, Saito Reiko, Kawakita Aoi, Eguchi Mami, Goto Motohide, Kubo Kazuyasu, Kawagoe Rinko, Kawada Yasusada, Kusuhara Koichi
発行年月 2017/05
概要 BACKGROUND:Little is known regarding the relationships among circulating brain-derived neurotrophic factor (BDNF) levels and glucose or insulin in children and adolescents. The objective of this study was to investigate whether circulating BDNF levels would change during the oral glucose tolerance test (OGTT).METHODS:We performed the OGTT and measured the serial changes in BDNF levels in both plasma and serum.RESULTS:There were 22 subjects in the normal type (N) group and 20 in the borderline/diabetic type (B/D) group, defined by the results of the OGTT. Serum levels of BDNF were almost five times higher and plasma levels gradually decreased during the OGTT, whereas serum levels showed no significant change. The reduction of plasma BDNF level changes from baseline to 120 min were significantly different between the N and B/D groups (36.3% vs. 20.8%, p=0.023).CONCLUSIONS:Our results showed that plasma levels of BDNF are more sensitive to acute changes in glucose or insulin levels than serum.
DOI 10.1515/jpem-2016-0344
PMID 28328533